WARNING: Life-threatening allergic reactions have occurred in some patients during VIMIZIM® (elosulfase alfa) infusions and up to 3 hours after infusion. Patients with acute respiratory illness may be at increased risk and require additional monitoring.

Derric’s story

quotes Probably the biggest benefit I’ve experienced has been in endurance, and being able to do more things. I can be more active. quotes

Get to know how Derric feels about his weekly treatment with VIMIZIM®
(elosulfase alfa).

“My infusion day usually starts early. I get to the clinic at 8 am and eat the breakfast I brought with me while they get everything ready for my infusion. They start by checking to make sure I am healthy enough for treatment that day. Then, they order the infusion from the pharmacy, which can take a little while. From start to finish, the infusion itself can take several hours.


During that time, I’m usually in a bed or a chair. Other than not being able to move around that much, I can do whatever I want. There’s a lot of downtime, so I’m able to socialize with friends in the clinic or spend time with my sister who receives infusions with me. I also use my iPad®a to read eBooks, catch up on articles I’ve saved for infusion day, or play games. Some of my favorite games that help pass the time are Tiny Wings, Peggle, Plants vs Zombies, and Harbor Master. I also listen to music during infusions. Music is especially helpful for relaxing, because it drowns out the background noise of the busy room.

At different times, the nurses come by to check on me and make sure the infusion is going well. I’m very close with the nurses I see every week. You develop relationships with them. Knowing they’re there, and that they know exactly what to expect from the infusion process, is reassuring.

When I first started VIMIZIM, I didn’t know what to expect from the year long trial. But soon after I started, I made the decision to stick with it. It’s been just over 2 years, and I’ve only missed 1 appointment. I’d say the sooner you can commit to this being something that’s going to benefit you for your whole life, the better it will be for you. Probably the biggest benefit I’ve experienced has been in endurance and being able to do more things. I can be more active. Maybe I lose a day once a week, but I’m more active for the other 6 days. And that is valuable to me.”

a iPad is a trademark of Apple, Inc., registered in the U.S. and other countries.


VIMIZIM® (elosulfase alfa) is indicated for patients with Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome).

Important Safety Information

Life-threatening allergic reactions, known as anaphylaxis, can occur during VIMIZIM® (elosulfase alfa) infusions. Typical signs of anaphylaxis include cough, rash, throat tightness, hives, flushing, changes in skin color, low blood pressure, shortness of breath, chest pain, and gastrointestinal symptoms such as nausea, abdominal pain, retching, and vomiting. Contact your doctor or get medical help right away if these symptoms occur during or after VIMIZIM infusions. If you have a respiratory illness, you may be at risk for a sudden worsening of your condition, and you may require additional monitoring.

VIMIZIM is a prescription medicine. Before treatment with VIMIZIM, it is important to discuss your medical history with your doctor. Tell your doctor if you are sick or taking any medication and if you are allergic to any medicines. Also tell your doctor if you are pregnant, planning to become pregnant, or are a nursing mother. Your doctor will decide if VIMIZIM is right for you. If you have questions or would like more information about VIMIZIM, contact your doctor.

Anaphylaxis can occur during any VIMIZIM infusion and up to three hours after any infusion, and hypersensitivity reactions have been observed as early as 30 minutes from the start of infusion but as late as six days after infusion.

Serious and severe reactions can happen with VIMIZIM treatment, including life-threatening allergic reactions (anaphylaxis), hives, swelling, cough, shortness of breath, and flushing. You should receive medication such as antihistamines before VIMIZIM infusions to reduce the risk of reactions. If a reaction occurs, the infusion should be slowed or stopped and you may be given additional medication. If a severe reaction occurs, the infusion should be stopped immediately and you will receive appropriate medical treatment.

If you have acute febrile or respiratory illness at the time of VIMIZIM infusion you may be at higher risk of life-threatening complications from hypersensitivity reactions. If you use supplemental oxygen or continuous positive airway pressure (CPAP) you should have it available during your infusion in the event of a sudden reaction, or extreme drowsiness/sleep from antihistamines.

Spinal cord damage may occur due to the natural MPS IVA disease process. Signs of spinal cord injury include back pain, numbness and paralysis, and loss of bladder and bowel control. Contact your doctor immediately if you develop any of these symptoms.

The most common side effects reported during VIMIZIM infusions included fever, vomiting, headache, nausea, abdominal pain, chills, and fatigue. These are not all of the possible side effects with VIMIZIM. Talk to your doctor if you have any symptoms that bother you or that do not go away.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

For more information, call BioMarin RareConnections™ at 1-866-906-6100.


BioMarin Pharmaceutical Inc.

Novato, CA 94949

BioMarin RareConnections™: 1-866-906-6100